Key result
Caffeine citrate (n=82) and aminophylline (n=98) were equally effective in preventing apnea and bradycardia in premature neonates, but caffeine citrate resulted in less tachycardia.
Why the study?
Does caffeine citrate compared to aminophylline prevent apnea and bradycardia with fewer adverse effects in premature neonates?
Does caffeine citrate compared to aminophylline prevent apnea and bradycardia with fewer adverse effects in premature neonates?
Caffeine citrate is preferred over aminophylline for apnea and bradycardia prophylaxis in premature neonates due to a better safety profile with equal efficacy.
May favor caffeine citrate for fewer tachycardia episodes in observational data; leaves open confirmation by randomized trials.
We investigated the efficacy and adverse effects of aminophylline and caffeine citrate in 180 premature neonates for 10 days and nights. Aminophylline (n = 98) and caffeine citrate (n = 82) were equally effective in preventing apnea and bradycardia. The caffeine citrate group had a lower median heart rate on day 3, fewer neonates with tachycardia and a smaller amount of gastric aspirate on day 7. The need for mononasal continuous positive airway pressure and respirator therapy was similar in both groups. We conclude that caffeine citrate is the drug of choice for apnea and bradycardia prophylaxis in premature neonates with a gestational age < or = 33 full weeks.
No takes yet. Share an insight, caveat, or question.
Larsen et al. (1995) studied Apnea and bradycardia in premature neonates (n=180). Caffeine citrate vs. Aminophylline was evaluated on Prevention of apnea and bradycardia. Caffeine citrate (n=82) and aminophylline (n=98) were equally effective in preventing apnea and bradycardia in premature neonates, but caffeine citrate resulted in less tachycardia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: