Key result
Preoperative serum uric acid ≥ 373.5 μmol/L was independently associated with increased in-hospital mortality in patients with type A aortic dissection (OR 1.022; 95% CI 1.000-1.044; P=0.048).
Why the study?
The study was conducted to measure preoperative uric acid concentration in patients with type A aortic dissection and evaluate its value for predicting in-hospital mortality.
Does elevated preoperative serum uric acid predict in-hospital mortality in patients with type A acute aortic dissection?
Cohort (n=747)
No
Does elevated preoperative serum uric acid predict in-hospital mortality in patients with type A acute aortic dissection?
Odds Ratio: 1.022 (95% CI 1–1.044)
Absolute Event Rate: 3.8% vs 0.7%
p-value: p=0.048
Elevated preoperative serum uric acid (≥ 373.5 μmol/L) is an independent predictor of in-hospital mortality in patients with type A acute aortic dissection.
OBJECTIVE: To measure the preoperative uric acid (UA) concentration in patients with type A aortic dissection (TAAD), and to assess its value in predicting in-hospital mortality. METHODS: A total of 747 patients with TAAD between January 2016 and December 2022 were enrolled. The patients were divided into a survivor group and a non-survivor group. The clinical data of the two groups were compared. Univariate and multiple logistic regression analyses were performed to determine risk factors related to in-hospital mortality. RESULTS: Compared with survivors, non-survivors had significantly higher serum uric acid levels (486.84 ± 127.59 vs 419.49 ± 141.02, P = 0.040). The incidence of in-hospital death increased along with higher UA levels (3.8% vs 0.7%, P = 0.007). Serum UA ≥ 373.5 μmol/L had 89.5% sensitivity and 41.3% specificity for predicting in-hospital death (area under the curve = 0.659, 95% CI: 0.554-0.765, P < 0.05). In the multivariable logistic model, Serum UA ≥ 373.5 μmol/L was independently associated with in-hospital mortality (OR = 1.022, 95% CI: 1.000-1.044, P = 0.048). CONCLUSION: Serum UA resulted as an independent predictor of adverse prognosis in patients with TAAD, and thus could be used as an effective tool for the risk-stratification of patients with TAAD.
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Hongyan et al. (2023) conducted a cohort in Type A aortic dissection (TAAD) (n=747). Preoperative serum uric acid ≥ 373.5 μmol/L vs. Lower serum uric acid levels was evaluated on In-hospital mortality (OR 1.022, 95% CI 1.000-1.044, p=0.048). Preoperative serum uric acid ≥ 373.5 μmol/L was independently associated with increased in-hospital mortality in patients with type A aortic dissection (OR 1.022; 95% CI 1.000-1.044; P=0.048).
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