Key result
Transfemoral TAVI reduced midterm all-cause mortality compared to the transapical approach (OR 0.85; 95% CI 0.80-0.90), alongside reduced risks of periprocedural bleeding and stroke.
Why the study?
Does the transfemoral approach reduce mortality and complications compared to the transapical approach in patients undergoing TAVI?
Population
10,468 patients with aortic stenosis undergoing transcatheter aortic valve implantation across 13 studies
Comparison
Transfemoral (TF) approach for TAVI vs Transapical (TA) approach for TAVI
Design
Meta-analysis
Follow-up
median 365 days (range 222-400)
Authors
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Prioritizes transfemoral TAVI when feasible; reinforces guidelines and extends meta-analytic support for preferred access.
Meta-Analysis (n=10,468)
Does the transfemoral approach reduce mortality and complications compared to the transapical approach in patients undergoing TAVI?
Odds Ratio: 0.85 (95% CI 0.8–0.9)
The transfemoral approach for TAVI is associated with reduced periprocedural complications and lower midterm mortality compared to the transapical approach.
Conrotto et al. (2014) conducted a meta-analysis in aortic stenosis (n=10,468). Transfemoral (TF) approach vs. Transapical (TA) approach was evaluated on all-cause mortality after at least 1-year follow-up (OR 0.85, 95% CI 0.80-0.90). Transfemoral TAVI reduced midterm all-cause mortality compared to the transapical approach (OR 0.85; 95% CI 0.80-0.90), alongside reduced risks of periprocedural bleeding and stroke.
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