Key result
The ST/HR slope did not correlate with the severity of coronary artery lesions (r=0.24), whereas exercise hemodynamic variables such as the CI/PCP ratio correlated significantly with the Gensini score (r=0.69, p<0.001).
Why the study?
Does the ST/HR slope or exercise hemodynamic variables predict the severity of coronary artery lesions in patients with effort angina pectoris?
Cross-Sectional (n=29)
No
Does the ST/HR slope or exercise hemodynamic variables predict the severity of coronary artery lesions in patients with effort angina pectoris?
Effect estimate: r=0.69 for CI/PCP; r=0.24 for ST/HR slope
p-value: p=<0.001
Exercise hemodynamic variables measured by right heart catheterization, but not the ST/HR slope, are useful predictors of the severity of coronary artery lesions in patients with effort angina pectoris.
Exercise hemodynamics were associated with lesion severity unlike ST/HR slope; hypothesis-generating and should not yet change practice.
This study evaluated the clinical value of the ST/HR slope and exercise hemodynamic variables for the severity of coronary artery lesions. Twenty-nine patients with effort angina pectoris underwent ergometer exercise during right side heart catheterization. The ST/HR slope failed to differentiate three groups stratified by the number of involved coronary vessels. The ST/HR slope was uncorrelated with the Gensini score (r = 0.24). By contrast, pulmonary capillary pressure (PCP), cardiac output index (CI) and CI/PCP at peak exercise correlated significantly with the Gensini score (r = 0.73, 0.53 and 0.69, respectively). We conclude that the ST/HR slope is not a useful predictor of the severity of coronary artery lesions, while exercise hemodynamic variables measured by right side heart catheter are useful.
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YAMASE et al. (1993) conducted a cross-sectional in Effort angina pectoris (n=29). ST/HR slope and exercise hemodynamic variables vs. Coronary angiography (Gensini score and number of diseased vessels) was evaluated on Correlation of ST/HR slope and exercise hemodynamic variables with the Gensini score (r=0.69 for CI/PCP; r=0.24 for ST/HR slope, p=<0.001). The ST/HR slope did not correlate with the severity of coronary artery lesions (r=0.24), whereas exercise hemodynamic variables such as the CI/PCP ratio correlated significantly with the Gensini score (r=0.69, p<0.001).
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