Key result
Correct prescription of gastroprotective strategies in high-risk NSAID users increased from 6.9% in 1996 to 39.4% in 2006 (P<0.01).
Why the study?
How have prescription rates of gastroprotective strategies for NSAID users changed between 1996 and 2006?
Population
50,126 NSAID users ≥50 years from the Integrated Primary Care Information database
Design
Cohort
Follow-up
1996 to 2006
Authors
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Suboptimal gastroprotection persists in most high-risk NSAID users; leaves open whether targeted interventions can close remaining gaps.
Cohort (n=50,126)
How have prescription rates of gastroprotective strategies for NSAID users changed between 1996 and 2006?
Absolute Event Rate: 39.4% vs 6.9%
p-value: p=<0.01
Although the use of gastroprotective strategies in high-risk NSAID users improved significantly from 1996 to 2006, approximately 60% of these patients still remain inadequately protected.
Valkhoff et al. (2010) conducted a cohort in NSAID users at risk of upper-gastrointestinal complications (n=50,126). Gastroprotective strategies (co-prescription of gastroprotective agents or COX-2 inhibitor) vs. No preventive strategy was evaluated on Correct prescription of preventive strategies in high-risk NSAID users (p=<0.01). Correct prescription of gastroprotective strategies in high-risk NSAID users increased from 6.9% in 1996 to 39.4% in 2006 (P<0.01).
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