Key result
Serum cystatin C level was significantly positively correlated with brachial-ankle pulse wave velocity (r = 0.251, p < 0.001) in a Chinese general population cohort.
Why the study?
Is serum cystatin C level associated with arterial stiffness (baPWV) in the Chinese general population?
Cross-Sectional (n=748)
Is serum cystatin C level associated with arterial stiffness (baPWV) in the Chinese general population?
Effect estimate: r = 0.251
p-value: p=<0.001
Serum cystatin C is positively correlated with arterial stiffness in a general Chinese population with normal renal function, suggesting its potential as a biomarker for vascular risk.
Serum cystatin C may mark arterial stiffness in Chinese adults; hypothesis-generating and requires prospective validation before any clinical role.
BACKGROUND: The purpose of the study is to evaluate whether serum cystatin C level is associated with arterial stiffness independent of other risk factors in Chinese general population. HYPOTHESIS: Cystatin C is a predictable marker of arterial stiffness in Chinese general population. METHODS: Subjects are 748 persons (mean age, 38.8years) who attended a health checkup in Beijing, China. We measured brachial-ankle PWV (baPWV) by using an automatic oscillometric method, and the concentration of serum cystatin C was quantified. RESULTS: The level of baPWV showed a significantly positive correlation with BMI, SBP, DBP, TG, TC, cystatin C (r = 0.251, p < 0.001), and a negative correlation with HDL-C. And when adjustment for age, BMI, and cigarette smoking, these correlations remain significantly. CONCLUSION: Arterial stiffness increases with an increase in serum cystatin C level in Chinese general population with normal renal function.
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Yang et al. (2018) conducted a cross-sectional in General population (n=748). Serum cystatin C level was evaluated on Brachial-ankle pulse wave velocity (baPWV) (r = 0.251, p=<0.001). Serum cystatin C level was significantly positively correlated with brachial-ankle pulse wave velocity (r = 0.251, p < 0.001) in a Chinese general population cohort.
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