CAR T‐Cell Therapy–Associated Parkinsonism: Need for Phenotype Characterization and Targeted Management

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CAR T-cell therapy is associated with parkinsonism, necessitating specific phenotype characterization and targeted management strategies. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Katarina Rukavina; Johannes Malleike; Thorsten Suess; Maria Gavriilaki; Doreen Gruber; Georg Ebersbach

doi:10.1002/mdc3.70798

August 30, 2026Movement Disorders Clinical PracticeOpen Access

CAR T‐Cell Therapy–Associated Parkinsonism: Need for Phenotype Characterization and Targeted Management

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Key Points

Characterize the clinical presentation of parkinsonism following CAR T-cell therapy to support targeted management strategies.
Assessed clinical reports and phenotypic presentations of secondary movement disorders emerging after CAR T-cell immunotherapy.
Identified parkinsonian features, including bradykinesia and rigidity, as distinct neurotoxic complications of CAR T-cell therapy.
Highlighted the lack of standardized phenotypic characterization and management protocols for therapy-associated movement disorders.

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Implication

Clinical review highlights CAR T-cell therapy–associated parkinsonism in cancer patients, suggesting an urgent need for phenotypic characterization and targeted management.

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Cite This Study

Rukavina et al. (2026) studied this question.

synapsesocial.com/papers/6a97e249c562ede874ec652b https://doi.org/10.1002/mdc3.70798

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CAR T‐Cell Therapy–Associated Parkinsonism: Need for Phenotype Characterization and Targeted Management

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

CAR T‐Cell Therapy–Associated Parkinsonism: Need for Phenotype Characterization and Targeted Management

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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