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September 2, 2026Retina

Treatment of foveal-involving tractional retinal detachments from proliferative diabetic retinopathy with intravitreal anti-VEGF therapy

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Authors

NMNihaal MehtaGHG. Baker Hubbard

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Overview

Retrospective study reveals foveal reattachment and visual improvement following serial anti-VEGF therapy in proliferative diabetic retinopathy, suggesting an alternative to immediate vitrectomy.

Key Points

  • To evaluate the clinical and anatomic outcomes of serial intravitreal anti-VEGF therapy in patients with fovea-off tractional retinal detachment secondary to proliferative diabetic retinopathy.
  • Retrospective medical record review of 12 eyes from 10 patients presenting with fovea-off tractional retinal detachment from proliferative diabetic retinopathy treated with serial anti-VEGF injections.
  • Assessed visual acuity, anatomical foveal reattachment, need for surgical vitrectomy, injection frequency, and total injections over a mean follow-up period of 27.8 months.
  • Foveal reattachment was achieved with anti-VEGF therapy alone in 75% of eyes (n = 9/12), requiring an average of 7 injections given at a mean interval of 2.3 months, with an average reattachment time of 15 months.
  • Mean logMAR visual acuity improved from 1.79 (Snellen equivalent 20/1233) at presentation to 1.6 (20/790) at 6 months, 1.4 (20/466) at 12 months, and 1.36 (20/453) at final follow-up (1.01 [20/204] among eyes achieving foveal reattachment).

Cite This Study

Mehta et al. (2026) studied this question.

synapsesocial.com/papers/6a97e275c562ede874ec68cdhttps://doi.org/10.1097/iae.0000000000005004
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