What does this research mean for the field?

Fisetin attenuates uterine leiomyoma progression in rats by reducing sex hormones, inflammation, and fibrosis through the modulation of S1P/SphK1, TGF-β, and HMGB1 signaling pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the therapeutic efficacy and underlying molecular mechanisms of fisetin against experimentally induced uterine leiomyoma.

September 2, 2026Journal of Biochemical and Molecular ToxicologyOpen Access

Fisetin Attenuates Uterine Leiomyoma in Rats: Potential Crosstalk Between HMGB1, SphK1/S1P, and TGF‐β Signaling

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Authors

NMNashwa MaghrabyAssiut University EKEsraa KhalafAssiut University MHMarwa T. HussienAssiut University

Discussion

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Implication

Preclinical study reveals fisetin reduces fibrotic remodeling and tumor signaling in rats with uterine leiomyoma, suggesting a potential uterus-preserving therapy.

Key Points

To evaluate the therapeutic efficacy and underlying molecular mechanisms of fisetin against experimentally induced uterine leiomyoma.
Monosodium glutamate (MSG) was administered to adult female rats to induce uterine leiomyoma across four experimental groups: Control, FIS, UL, and UL + FIS.
Serum estradiol, progesterone, and S1P levels were quantified using ELISA, while uterine architecture and collagen deposition were assessed via H&E and Masson's Trichrome staining.
Gene and protein expression profiles of SphK1, TGF-β1, HMGB1, TNF-α, IL-1β, and α-SMA were evaluated using qPCR and immunohistochemistry.
Fisetin administration significantly reduced elevated serum concentrations of estradiol, progesterone, and S1P compared to untreated leiomyoma controls.
Treatment markedly suppressed expression of proinflammatory mediators (HMGB1, TNF-α, IL-1β) and profibrotic markers (SphK1, TGF-β1, α-SMA).
Histopathological analysis demonstrated significant reduction in fibrotic tissue remodeling and notable restoration of normal uterine architecture.

Cite This Study

Maghraby et al. (2026) studied this question.

synapsesocial.com/papers/6a97e275c562ede874ec6904 https://doi.org/10.1002/jbt.71105

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Implication

Preclinical study reveals fisetin reduces fibrotic remodeling and tumor signaling in rats with uterine leiomyoma, suggesting a potential uterus-preserving therapy.

Fisetin Attenuates Uterine Leiomyoma in Rats: Potential Crosstalk Between HMGB1, SphK1/S1P, and TGF‐β Signaling

Discussion

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Implication

Key Points

Cite This Study

Fisetin Attenuates Uterine Leiomyoma in Rats: Potential Crosstalk Between HMGB1, SphK1/S1P, and TGF‐β Signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

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