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September 2, 2026Medicina Clínica PrácticaOpen Access

Association of IgG and C3 deposit intensity with desmoglein 1 and 3 antibody concentrations in pemphigus patients

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Authors

GKGaukhar KoylibaevaUSUlugbek SabirovSKSherzod Khonkhodjaev

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Overview

Observational study reveals tissue IgG and C3 deposit intensity correlates with circulating anti-desmoglein levels in pemphigus, indicating complementary value of immunofluorescence and ELISA.

Key Points

  • To assess the correlation between the intensity of tissue-bound IgG and complement component 3 (C3) deposits and circulating anti-desmoglein 1 (Dsg1) and 3 (Dsg3) antibody concentrations in pemphigus patients.
  • Conducted a single-centre prospective observational cross-sectional study in 50 pemphigus patients (42 pemphigus vulgaris, 8 seborrheic pemphigus).
  • Measured serum anti-Dsg1 and anti-Dsg3 antibody concentrations in all 50 patients using ELISA.
  • Performed direct immunofluorescence (DIF) on perilesional skin biopsies in 39 patients to grade IgG and C3 deposit intensity.
  • Tissue IgG deposition intensity correlated positively with serum anti-Dsg3 (rs = 0.71, 95% CI 0.48–0.85; p < 0.001) and anti-Dsg1 (rs = 0.67, 95% CI 0.42–0.82; p < 0.001), with strong deposits showing approximately 2.3-fold higher anti-Dsg1 levels than weak deposits.
  • IgG and C3 deposit intensity demonstrated a strong direct correlation (rs = 0.78, 95% CI 0.59–0.89; p < 0.001).
  • Serological profiles differed significantly between subtypes (p = 0.04, n = 6), characterized by predominant anti-Dsg3 elevation in pemphigus vulgaris versus predominant anti-Dsg1 elevation in seborrheic pemphigus.

Cite This Study

Koylibaeva et al. (2026) studied this question.

synapsesocial.com/papers/6a97e275c562ede874ec6995https://doi.org/10.1016/j.mcpsp.2026.100555
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