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September 2, 2026HLAOpen Access

Discovery of the Novel HLA‐DQB1*05:386 Allele in a Brazilian Volunteer Donor

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Authors

EMEmerson Fernando Garcia MachadoJLJosiane Aparecida LinharesMDMaria Eduarda Dugonski

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Overview

Genetic sequencing identifies the novel HLA-DQB1*05:386 allele in a volunteer donor, expanding known human leukocyte antigen diversity.

Key Points

  • Characterize a novel human leukocyte antigen allele identified in a Brazilian volunteer donor.
  • Sequenced and analyzed the HLA-DQB1 locus of a Brazilian volunteer donor to identify sequence divergence from standard references.
  • Identified and designated the novel allele as HLA-DQB1*05:386.
  • Determined that HLA-DQB1*05:386 differs from the reference allele HLA-DQB1*05:01:01:01 by a single non-synonymous substitution located in exon 4.

Cite This Study

Machado et al. (2026) studied this question.

synapsesocial.com/papers/6a97e29ec562ede874ec6d5dhttps://doi.org/10.1111/tan.70959
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