Key result
The presence of carotid intraplaque neovascularization did not significantly predict major adverse cardiovascular events (HR 0.996) compared to its absence in patients with coronary artery disease.
Why the study?
The predictive value of carotid intraplaque neovascularization for cardiovascular outcomes in patients with coronary artery disease needed investigation.
Does the presence of carotid intraplaque neovascularization predict major adverse cardiovascular events in patients with stable coronary artery disease?
Observational (n=217)
No
Does the presence of carotid intraplaque neovascularization predict major adverse cardiovascular events in patients with stable coronary artery disease?
The presence of carotid intraplaque neovascularization detected by contrast-enhanced ultrasound does not predict long-term cardiovascular outcomes better than conventional clinical factors in patients with stable coronary artery disease.
Answers are grounded in this paper and cite their sources.
Does not support carotid IPN for MACE prediction in stable CAD; leaves open its incremental value over clinical factors.
OBJECTIVE: To investigate the predictive value of intraplaque neovascularization (IPN) for cardiovascular outcomes. MATERIALS AND METHODS: We evaluated 217 patients with coronary artery disease (CAD) (158 men; mean age, 68 ± 10 years) with a maximal carotid plaque thickness ≥ 1.5 mm for the presence of IPN using contrast-enhanced ultrasonography. We compared patients with (n = 116) and without (n = 101) IPN during the follow-up period and investigated the predictors of major adverse cardiovascular events (MACE), including cardiac death, myocardial infarction, coronary artery revascularization, and transient ischemic accident/stroke. The presence of IPN could not predict MACE. CONCLUSION: The presence of IPN was related to a higher plaque thickness but could not predict cardiovascular outcomes better than conventional clinical factors in patients with CAD.
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Chung et al. (2020) conducted an observational in Coronary artery disease with carotid plaque (n=217). Carotid intraplaque neovascularization (IPN) vs. Absence of IPN was evaluated on Major adverse cardiovascular events (MACE) (HR 0.996, 95% CI 0.335-2.965, p=0.995). The presence of carotid intraplaque neovascularization did not significantly predict major adverse cardiovascular events (HR 0.996) compared to its absence in patients with coronary artery disease.
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