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January 1, 2021Gerontology

Carotid Intraplaque Neovascularization Predicts Ischemic Stroke Recurrence in Patients with Carotid Atherosclerosis

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Why the study?

It was unknown whether carotid intraplaque neovascularization characterized by contrast-enhanced ultrasound is associated with ischemic stroke recurrence in patients with carotid atherosclerosis.

Does intraplaque neovascularization (IPN) assessed by CEUS predict ischemic stroke recurrence in patients with carotid atherosclerosis?

Population

155 consecutive patients with a recent stroke and ipsilateral carotid atherosclerotic plaque

Comparison

Presence and grade of intraplaque neovascularization on contrast-enhanced ultrasound

Design

Prospective study

Follow-up

24 months

Authors

YSYan SongYDYing DangJWJichang Wang

Discussion

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Member takes

Overview

Should not yet change post-stroke imaging or therapy; leaves open CEUS-IPN as a biomarker for secondary-prevention trials.

Structured PICO

Does intraplaque neovascularization (IPN) assessed by CEUS predict ischemic stroke recurrence in patients with carotid atherosclerosis?

P
Population
155 consecutive patients with a recent stroke and at least one atherosclerotic plaque in the carotid artery on the side consistent with symptoms
I
Intervention
Intraplaque neovascularization (IPN) assessment by contrast-enhanced ultrasound (CEUS)
C
Comparator
Absence of IPN or lower grade IPN
O
Outcome
Ischemic stroke recurrence at 24 months follow-uphard clinical

Intraplaque neovascularization assessed by contrast-enhanced ultrasound is an independent predictor of stroke recurrence in patients with recent ischemic stroke and carotid atherosclerosis.

Cite This Study

Song et al. (2021) studied this question.

synapsesocial.com/papers/6a7eb68086f8ecc58a4f794fhttps://doi.org/10.1159/000511360
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plaque neovascularization detected with contrast‐enhanced ultrasound predicts ischaemic stroke recurrence in patients with carotid atherosclerosis2020 · 59 citations
  2. 2Correlation of Carotid Plaque Neovascularization Detected by Using Contrast-enhanced US with Clinical Symptoms2009 · 170 citations
  3. 3Contrast-Enhanced Ultrasound for the Evaluation of Neovascularization in Atherosclerotic Carotid Artery Plaques2014 · 96 citations
  4. 4New Approach to Stroke Subtyping: The A-S-C-O (Phenotypic) Classification of Stroke2009 · 330 citations
  5. 5Carotid intraplaque neovascularization predicts coronary artery disease and cardiovascular events2019 · 104 citations