Key result
CEUS-detected plaque neovascularization was independently associated with an increased risk of stroke recurrence in patients with recent stroke and carotid atherosclerosis (HR 6.57; 95% CI 1.66-26.01).
Why the study?
Plaque neovascularization marks carotid plaque vulnerability and can be visualized with CEUS, but its association with stroke recurrences in patients with recent stroke and carotid atherosclerosis was unclear.
Does plaque neovascularization detected with contrast-enhanced ultrasound predict stroke recurrence in patients with recent stroke and carotid atherosclerosis?
Population
78 consecutive patients with a recent stroke and internal carotid artery atherosclerotic plaque
Comparison
Grades of CEUS-detected plaque neovascularization
Design
Prospective cohort study
Follow-up
Median 14.1 (interquartile range, 9.5-19.6) months
Authors
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May aid post-stroke risk stratification in carotid disease; hypothesis-generating pending prospective validation.
Cohort (n=78)
Does plaque neovascularization detected with contrast-enhanced ultrasound predict stroke recurrence in patients with recent stroke and carotid atherosclerosis?
Hazard Ratio: 6.57 (95% CI 1.66–26.01)
Plaque neovascularization detected by contrast-enhanced ultrasound is a strong independent predictor of stroke recurrence in patients with recent stroke and carotid atherosclerosis.
Camps‐Renom et al. (2020) conducted a cohort in Recent stroke and carotid atherosclerosis (n=78). CEUS-detected plaque neovascularization vs. Absence or lower extent of neovascularization was evaluated on Stroke recurrence (HR 6.57, 95% CI 1.66-26.01). CEUS-detected plaque neovascularization was independently associated with an increased risk of stroke recurrence in patients with recent stroke and carotid atherosclerosis (HR 6.57; 95% CI 1.66-26.01).