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September 2, 2026BMC Health Services ResearchOpen Access

Systems engineering interventions in healthcare services and systems – a systematic review and framework development

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Authors

YYYin YuanTRThomas RichardsJHJi Han

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Overview

Systematic review reveals distinct roles for systems engineering and user-centred design in healthcare, highlighting how matching methodologies to delivery levels optimizes systemic outcomes.

Key Points

  • To identify systems engineering and design methodologies applied to healthcare systems and develop a multi-level conceptual framework guiding methodological selection across micro, meso, and macro levels.
  • Conducted a systematic review across 11 databases (including Embase, Medline, and Scopus) on November 4, 2024, identifying reviews published within the previous five years.
  • Identified and synthesized 32 secondary reviews encompassing 1,127 primary studies that applied systems-level engineering and design methodologies in healthcare.
  • Applied an a priori framework synthesis approach to categorize methodologies and map their interactions across micro (patient), meso (service), and macro (system) tiers.
  • Service design, improvement, and development emerged as the primary intervention domains, with user-centred design and co-design delivering greatest efficacy for patient-level usability and engagement.
  • Macro-level systemic change and policy transformation required systems thinking combined with structured stakeholder involvement to manage organizational complexity.
  • Major evidence gaps persist regarding standardized outcome metrics, real-world implementation evaluations, and adaptability to resource-constrained or culturally diverse healthcare environments.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2d9c562ede874ec7304https://doi.org/10.1186/s12913-026-15420-2
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