What does this research mean for the field?

Increased bone marrow fibrosis (Grade 2 or 3) and elevated serum lactate dehydrogenase levels are independent predictors of synchronous extramedullary disease in patients with newly diagnosed multiple myeloma. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the incidence of bone marrow fibrosis in newly diagnosed multiple myeloma and evaluate its relationship with synchronous soft tissue extramedullary disease at diagnosis.

September 2, 2026European Journal Of HaematologyOpen Access

Bone Marrow Fibrosis as a Predictor of Extramedullary Disease in Multiple Myeloma

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Authors

HSHilal Senkal AAAli Yılmaz Altay EIEmine Göknur Işık

Discussion

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Overview

Retrospective cohort study reveals bone marrow fibrosis predicts synchronous extramedullary disease in multiple myeloma, highlighting marrow scarring as a clinical marker for tumor spread.

Key Points

To determine the incidence of bone marrow fibrosis in newly diagnosed multiple myeloma and evaluate its relationship with synchronous soft tissue extramedullary disease at diagnosis.
Conducted a retrospective chart review of 356 patients with multiple myeloma to evaluate clinical characteristics, histological features, and treatment outcomes.
Graded bone marrow fibrosis (BMF) using WHO criteria, categorizing Grade 2–3 as the fibrosis group and Grade 0–1 as the non-fibrosis group, alongside identifying extramedullary disease originating from hematogenous spread.
Grade 2 or higher BMF was observed in 146 of 356 patients (41.0%) and was present in 40 of the 52 patients with extramedullary disease (p < 0.01).
Multivariable logistic regression identified BMF status as an independent predictor of synchronous extramedullary disease (OR = 3.200, 95% CI: 1.010–10.141, p = 0.048).
Elevated serum lactate dehydrogenase levels independently predicted synchronous extramedullary involvement (OR = 1.003, 95% CI: 1.000–1.005, p = 0.037).

Cite This Study

Senkal et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2d9c562ede874ec73b7 https://doi.org/10.1111/ejh.70314

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September 2, 2026European Journal Of HaematologyOpen Access

Bone Marrow Fibrosis as a Predictor of Extramedullary Disease in Multiple Myeloma

View Full Paper

Ask AI

Bookmark

Authors

HSHilal Senkal AAAli Yılmaz Altay EIEmine Göknur Işık

Discussion

Member takes

Overview

Retrospective cohort study reveals bone marrow fibrosis predicts synchronous extramedullary disease in multiple myeloma, highlighting marrow scarring as a clinical marker for tumor spread.

Key Points

To determine the incidence of bone marrow fibrosis in newly diagnosed multiple myeloma and evaluate its relationship with synchronous soft tissue extramedullary disease at diagnosis.
Conducted a retrospective chart review of 356 patients with multiple myeloma to evaluate clinical characteristics, histological features, and treatment outcomes.
Graded bone marrow fibrosis (BMF) using WHO criteria, categorizing Grade 2–3 as the fibrosis group and Grade 0–1 as the non-fibrosis group, alongside identifying extramedullary disease originating from hematogenous spread.
Grade 2 or higher BMF was observed in 146 of 356 patients (41.0%) and was present in 40 of the 52 patients with extramedullary disease (p < 0.01).
Multivariable logistic regression identified BMF status as an independent predictor of synchronous extramedullary disease (OR = 3.200, 95% CI: 1.010–10.141, p = 0.048).
Elevated serum lactate dehydrogenase levels independently predicted synchronous extramedullary involvement (OR = 1.003, 95% CI: 1.000–1.005, p = 0.037).

Cite This Study

Senkal et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2d9c562ede874ec73b7 https://doi.org/10.1111/ejh.70314

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