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September 2, 2026Open Access

Synthesis and Biological Assessment of New Thiazolo3,2-a Pyrimidine Derivatives as Potential Antimicrobial Agents

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Authors

MAMahesh B. AutiMGMayur J. GawandeNHNilesh K. Halikar

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Overview

In vitro experimental study demonstrates antimicrobial activity of novel thiazolo[3,2-a] pyrimidines against bacteria and fungi, highlighting potential new anti-infective leads.

Key Points

  • To synthesize novel thiazolo[3,2-a] pyrimidine derivatives and evaluate their potential as antibacterial and antifungal agents, alongside their pharmacokinetic profiles.
  • Synthesized target compound 3 via reflux of ethyl 2-cyano-3,3-bis(methylthio)acrylate and 4-(2-aminothiazol-4-yl)benzonitrile in anhydrous K₂CO₃ and DMF solvent.
  • Confirmed chemical structures using infrared (IR) spectroscopy, ¹H nuclear magnetic resonance (NMR), and mass spectrometry.
  • Assessed antibacterial and antifungal activities against microbial panels and estimated lipophilicity (log P) and in silico ADME pharmacokinetic properties.
  • Successfully prepared and structurally characterized the novel thiazolo[3,2-a] pyrimidine scaffold derivatives.
  • Screening identified compounds 3a and 3c as possessing strong antimicrobial potential across the tested bacterial and fungal strains.
  • In silico computational modeling and log P analysis revealed favorable lipophilicity and drug-likeness parameters for the active derivatives.

Cite This Study

Auti et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2f6c562ede874ec768fhttps://doi.org/10.5281/zenodo.22206031
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