What question did this study set out to answer?

This work aimed to synthesize new heterocyclic derivatives based on thiazolidin-4-one scaffolds and evaluate their properties.

December 11, 2025International Journal of Quantum Chemistry

Synthesis, Characterization, DFT Analysis, and Antimicrobial Evaluation of Thiazolo4,5‐dPyrimidine and Thiazolo4,5‐bPyridine Derivatives

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Authors

AAAbdullah Yahya Abdullah AlzahraniUmm al-Qura University AGAmira A. GhoneimZagazig University WZWael A. ZordokZagazig University

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Implication

Synthesis and antimicrobial evaluation of thiazolidin-4-one derivatives revealed strong binding affinity in bacterial and malaria targets, indicating their potential use as antimicrobials.

Key Points

This work aimed to synthesize new heterocyclic derivatives based on thiazolidin-4-one scaffolds and evaluate their properties.
Synthesized thiazolidin-4-one derivatives condensed with guanidine hydrochloride.
Performed DFT calculations to predict electronic properties and molecular geometry.
Conducted molecular docking studies to assess binding interactions with antibacterial and antimalarial targets.
Compounds showed strong ligand-protein interactions and high binding affinity toward targets.
DFT analysis indicated favorable electronic properties and stability for synthesized derivatives.

Cite This Study

Alzahrani et al. (2025) studied this question.

synapsesocial.com/papers/69401b1e2d562116f28f77c1 https://doi.org/10.1002/qua.70127

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Implication

Synthesis and antimicrobial evaluation of thiazolidin-4-one derivatives revealed strong binding affinity in bacterial and malaria targets, indicating their potential use as antimicrobials.

Synthesis, Characterization, DFT Analysis, and Antimicrobial Evaluation of Thiazolo4,5‐dPyrimidine and Thiazolo4,5‐bPyridine Derivatives

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Implication

Key Points

Cite This Study

Synthesis, Characterization, DFT Analysis, and Antimicrobial Evaluation of Thiazolo4,5‐dPyrimidine and Thiazolo4,5‐bPyridine Derivatives

Discussion

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Implication

Key Points

Cite This Study

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