Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 30, 2013PLoS ONEOpen Access

Treatment with losartan or captopril reduced infection-induced T cell activation to control levels and diminished IFN-gamma and IL-17 production by CD4+ T cells by 67% and 70%, respectively.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does losartan or captopril reduce splenic T cell activation and inflammation in a murine model of cerebral malaria?

Population

C57BL/6 mice (8-12 weeks old) infected with Plasmodium berghei ANKA (rodent model of cerebral malaria).

Comparison

Losartan or captopril administered by gavage for… vs Vehicle-treated infected mice and naive control…

Design

Preclinical

Follow-up

Up to 10 days

Key result

Treatment with losartan or captopril reduced infection-induced T cell activation to control levels and diminished IFN-gamma and IL-17 production by CD4+ T cells by 67% and 70%, respectively.

Authors

JSJoão Luiz Silva‐FilhoMSMariana C. SouzaCFClaudio Teixeira Ferreira-DaSilva

Discussion

Loading...

Member takes

Overview

Does not support clinical use in malaria; hypothesis-generating for AT1 blockade in human cerebral malaria.

Structured PICO

Does losartan or captopril reduce splenic T cell activation and inflammation in a murine model of cerebral malaria?

P
Population
C57BL/6 mice infected with Plasmodium berghei ANKA to model cerebral malaria, treated with losartan or captopril for 6 days.
I
Intervention
Losartan (20 mg/kg/day) or captopril (20 mg/kg/day) administered by gavage for 6 days starting on the day of infection.
C
Comparator
Vehicle-treated infected mice and naive (non-infected) control mice.
O
Outcome
Splenic T cell activation (CD69 expression) and cytokine production (IFN-γ, IL-17) at day 6 post-infection.surrogate

Main Result

p-value: p=<0.05

Angiotensin II blockade with losartan or captopril reduces splenic T cell activation and inflammatory cytokine production in a murine model of cerebral malaria, suggesting a role for the AT1/Ang II axis in malaria pathogenesis.

Limitations

  • Animal model may not fully replicate human disease
  • Treatments provided only partial protection from cerebral malaria as mice still succumbed with high parasitemia

Cite This Study

Silva‐Filho et al. (2013) studied Plasmodium berghei ANKA infection (cerebral malaria model). Losartan or Captopril vs. Vehicle was evaluated on T cell activation (CD69 expression) and cytokine production (IFN-gamma and IL-17) (p=<0.05). Treatment with losartan or captopril reduced infection-induced T cell activation to control levels and diminished IFN-gamma and IL-17 production by CD4+ T cells by 67% and 70%, respectively.

synapsesocial.com/papers/6a97e2fdff0077060d8be901https://doi.org/10.1371/journal.pone.0062999
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II Induces Leukocyte–Endothelial Cell Interactions In Vivo Via AT <sub>1</sub> and AT <sub>2</sub> Receptor–Mediated P-Selectin Upregulation2000 · 161 citations
  2. 2Angiotensin II Induces Vascular Cell Adhesion Molecule-1 Expression In Rat Vasculature1999 · 378 citations
  3. 3Control of dendritic cell differentiation by angiotensin II2003 · 127 citations
  4. 4Regulating immunity to malaria2005 · 199 citations
  5. 5Protein Kinase C θ Deficiency Increases Resistance of C57BL/6J Mice toPlasmodium bergheiInfection-Induced Cerebral Malaria2010 · 15 citations