What does this research mean for the field?

Recent advancements in formulation science and drug delivery device technologies are overcoming the inherent delivery barriers of large molecule therapeutics, enabling a paradigm shift toward minimally invasive, patient-centric care and self-administration. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review delivery barriers for large molecule therapeutics and evaluate advancements in formulation science and device technologies that enable patient-centric care.

September 2, 2026AAPS OpenOpen Access

Advancements and challenges in large molecule drug delivery and devices for patient-centric care

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Authors

MBMayumi Bowen YAYillma Adam DCDebby ChangRoche (United States)

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Implication

Narrative review demonstrates advances in delivery devices for complex therapeutics in patients with chronic diseases, highlighting improved adherence through home administration.

Key Points

To review delivery barriers for large molecule therapeutics and evaluate advancements in formulation science and device technologies that enable patient-centric care.
Conducted a narrative mini-review summarizing delivery hurdles associated with large molecules such as monoclonal antibodies, recombinant proteins, and nucleic acids.
Synthesized recent developments in drug delivery devices, non-invasive administration routes, digital health integrations, and sustainable practices.
Delivery barriers for large molecules arise primarily from biological instability, high molecular weight, and structural complexity, necessitating invasive parenteral administration.
Adoption of advanced devices—including prefilled syringes, autoinjectors, and wearable injectors—enables reliable self-administration, home-based treatment, and improved patient compliance.
Formulation and nanotechnology innovations are expanding non-invasive or targeted routes, such as pulmonary, transdermal, ophthalmic, and neurological delivery.

Cite This Study

Bowen et al. (2026) studied this question.

synapsesocial.com/papers/6a97e318c562ede874ec7a44 https://doi.org/10.1186/s41120-026-00190-2

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Implication

Narrative review demonstrates advances in delivery devices for complex therapeutics in patients with chronic diseases, highlighting improved adherence through home administration.

Advancements and challenges in large molecule drug delivery and devices for patient-centric care

Discussion

Member takes

Implication

Key Points

Cite This Study

Advancements and challenges in large molecule drug delivery and devices for patient-centric care

Discussion

Member takes

Implication

Key Points

Cite This Study

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