What does this research mean for the field?

Exposure-based cognitive behavioral therapy reduces frustration as a transdiagnostic symptom in youth with clinical anxiety and irritability, whereas reductions in anger are specific to those treated for irritability. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether exposure-based cognitive behavioral therapy produces real-time reductions in both targeted and non-targeted emotional symptoms among youth treated for anxiety or irritability.

September 2, 2026JCPP AdvancesOpen Access

Ecological momentary assessment of targeted and non‐targeted symptom changes in clinical anxiety and irritability among children and adolescents receiving cognitive behavioral therapy

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Authors

LHLauren M. HenryVanderbilt University MBMeghan E. ByrneNational Institute of Mental Health JMJulia ModellNational Institute of Mental Health

Discussion

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Implication

Clinical trial analysis reveals exposure-based therapy reduces frustration across youth with anxiety and irritability, indicating frustration acts as a shared transdiagnostic treatment target.

Key Points

To evaluate whether exposure-based cognitive behavioral therapy produces real-time reductions in both targeted and non-targeted emotional symptoms among youth treated for anxiety or irritability.
Analyzed data from two exposure-based CBT trials involving youth with clinical anxiety (n = 92) and irritability (n = 39), alongside healthy controls (n = 57).
Youth completed ecological momentary assessment (EMA; 3 daily prompts over 7 days) at pre-, mid-, and post-treatment intervals.
Multilevel modeling assessed trajectories of self-reported frustration, anger, and worry across the treatment timeline.
Frustration decreased significantly over time across both clinical cohorts, improving as a non-targeted symptom in anxiety and as a targeted symptom in irritability.
Anger decreased significantly only among youth receiving treatment for irritability, whereas worry did not show significant changes over time in either clinical group.
Healthy volunteer youth maintained consistently low and stable symptom levels across all evaluation intervals.

Cite This Study

Henry et al. (2026) studied this question.

synapsesocial.com/papers/6a97e318c562ede874ec7b46 https://doi.org/10.1002/jcv2.70160

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Implication

Clinical trial analysis reveals exposure-based therapy reduces frustration across youth with anxiety and irritability, indicating frustration acts as a shared transdiagnostic treatment target.

Ecological momentary assessment of targeted and non‐targeted symptom changes in clinical anxiety and irritability among children and adolescents receiving cognitive behavioral therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Ecological momentary assessment of targeted and non‐targeted symptom changes in clinical anxiety and irritability among children and adolescents receiving cognitive behavioral therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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