What does this research mean for the field?

Cannabinoids are promising anticancer agents and therapeutic adjuvants that induce multiple forms of regulated cancer cell death through complex signaling pathways, though their clinical translation requires further investigation. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the molecular mechanisms by which natural and synthetic cannabinoids trigger regulated cell death in cancer and assess their therapeutic potential.

September 2, 2026BiomoleculesOpen Access

Cannabinoids in Cancer: Molecular Mechanisms of Tumor Cell Death and Translational Opportunities

View Full Paper

Ask AI

Bookmark

Authors

AMAlaa A. El El Moghrabi AKAli Al Khatib ICIsraa Ahmad Cheikh

Discussion

Member takes

Implication

Literature review reveals cannabinoid-mediated tumor cell death pathways across preclinical models, highlighting translational opportunities and adjuvant potential in oncology.

Key Points

To review the molecular mechanisms by which natural and synthetic cannabinoids trigger regulated cell death in cancer and assess their therapeutic potential.
Comprehensive literature review synthesizing preclinical and clinical evidence on natural and synthetic cannabinoids in oncology.
Evaluation of biological pathways modulating tumor progression, cell death induction, and synergy with standard anticancer treatments.
Cannabinoids suppress tumor growth, angiogenesis, and metastasis while inducing diverse regulated cell death pathways, including apoptosis, autophagy-dependent death, necroptosis, ferroptosis, and parthanatos.
Anticancer activity is driven through signaling networks including TRIB3/AKT/mTORC1, PI3K/AKT/mTOR, MAPK/ERK, and ceramide/Raf1/ERK/ROS cascades.
Cannabinoids synergize with conventional therapies to augment antitumor efficacy and offer established palliative benefits for chemotherapy-induced nausea, cachexia, and pain.

Cite This Study

Moghrabi et al. (2026) studied this question.

synapsesocial.com/papers/6a97e318c562ede874ec7b48 https://doi.org/10.3390/biom16091260

View Full Paper

Ask AI

Bookmark

Implication

Literature review reveals cannabinoid-mediated tumor cell death pathways across preclinical models, highlighting translational opportunities and adjuvant potential in oncology.

Cannabinoids in Cancer: Molecular Mechanisms of Tumor Cell Death and Translational Opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

Cannabinoids in Cancer: Molecular Mechanisms of Tumor Cell Death and Translational Opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider