Key result
Treatment with unfractionated heparin and intravenous rehydration successfully resolved a rare case of phlegmasia alba dolens complicated by rhabdomyolysis and acute kidney injury.
Case Report (n=1)
This case highlights the importance of early recognition and treatment of phlegmasia alba dolens complicated by rhabdomyolysis and acute kidney injury using parenteral anticoagulation and hydration.
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May support anticoagulation and hydration in phlegmasia alba dolens with rhabdomyolysis; hypothesis-generating and requires prospective validation.
A 57-year-old woman with obesity, severe dyslipidemia and hypertension presented with acute onset of excruciating pain at left leg followed by entire leg swelling without a specific provocation. Physical examination revealed a significant left lower limb oedema along with pale skin, livedo reticularis, poikilothermia, and diminished distal artery pulsation. Urgent vascular Doppler sonography of left lower limb showed obstructive venous thrombus and non-compressible vessel at level of iliofemoral vein. Arterial systems were without any obliteration but with relatively reduced flow to distal part. Blood test resulted in significantly raised creatinine and creatine kinase (CK) level. Diagnosis of phlegmasia alba dolens with complication of rhabdomyolysis and acute kidney injury had been made initially. The patient was treated with heparin as well as rehydration using saline solution and bicarbonate. Eventually, she had clinical improvement during hospitalization and been discharged with resolution of creatinine and CK level.
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Suciadi et al. (2021) conducted a case report in Phlegmasia alba dolens, rhabdomyolysis, acute kidney injury (n=1). Anticoagulation and rehydration was evaluated on Clinical improvement and resolution of deep vein thrombosis, creatinine, and creatine kinase levels. Treatment with unfractionated heparin and intravenous rehydration successfully resolved a rare case of phlegmasia alba dolens complicated by rhabdomyolysis and acute kidney injury.
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