Key result
High-dose irradiation and intensive chemotherapy reduced local recurrence (5.3% vs 47.5%) and prolonged median time to first metastasis (>15 vs 8 months) compared to less intensive therapy.
Why the study?
Does the combination of high-dose irradiation and intensive chemotherapy improve disease-free survival compared to radiation therapy alone or with less intensive drug therapy in patients with localized Ewing's sarcoma?
Cohort (n=59)
No
Does the combination of high-dose irradiation and intensive chemotherapy improve disease-free survival compared to radiation therapy alone or with less intensive drug therapy in patients with localized Ewing's sarcoma?
Absolute Event Rate: 5.3% vs 47.5%
High-dose irradiation combined with intensive chemotherapy appears to reduce local recurrence and delay metastasis in localized Ewing's sarcoma compared to radiation alone or with less intensive chemotherapy.
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Intensive therapy may lower recurrence in localized Ewing sarcoma; leaves open confirmation by randomized trials.
Fernández et al. (1974) conducted a cohort in Localized Ewing's sarcoma (n=59). High-dose irradiation and intensive chemotherapy vs. Radiation therapy alone or with less intensive drug therapy was evaluated on Local recurrence. High-dose irradiation and intensive chemotherapy reduced local recurrence (5.3% vs 47.5%) and prolonged median time to first metastasis (>15 vs 8 months) compared to less intensive therapy.
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