Key result
Infusion of 10 mg phentolamine significantly increased myocardial clearance of rubidium from 89.3 to 117.3 ml/min per 100 g myocardium in patients with recent myocardial infarction (P<0.01).
Why the study?
Does phentolamine infusion improve coronary blood flow (myocardial clearance of rubidium) in patients with recent myocardial infarction?
Does phentolamine infusion improve coronary blood flow (myocardial clearance of rubidium) in patients with recent myocardial infarction?
Phentolamine infusion significantly increases myocardial clearance of rubidium, suggesting improved coronary blood flow in patients with recent myocardial infarction.
May suggest coronary flow benefit from phentolamine post-MI; case-report data leave open any clinical role pending controlled trials.
The myocardial clearance of rubidium may be obtained by praecordial counting after intravenous injection of Rb-minus 86 Cl. Eight patients with recent myocardial infarction had this determination performed before and after the infusion of 10 mg phentolamine at a rate of 0.3 mg/minute. The average predrug myocardial clearance of Rb was 89.3 plus or minus 29.9 ml/min per 100 g myocardium. After phentolamine, the average myocardial clearance rose to 117.3 plus or minus 33.3 ml/min per 100 g myocardium (P LESS THAN 0.01). An explanation for this findings is presented as well as its possible clinical applications.
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Gould et al. (1975) studied recent myocardial infarction (n=8). phentolamine vs. predrug (baseline) was evaluated on myocardial clearance of rubidium (p=<0.01). Infusion of 10 mg phentolamine significantly increased myocardial clearance of rubidium from 89.3 to 117.3 ml/min per 100 g myocardium in patients with recent myocardial infarction (P<0.01).
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