What question did this study set out to answer?

The study evaluates the correlation between myocardial clearance of Rb 86 and coronary blood flow in the right and left ventricles.

August 1, 1963American Journal of Physiology-Legacy Content

Relationship of blood flow and myocardial Rb86 clearance in right and left ventricles

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Population

Dogs, including controls and a group with pulmonary embolism or obstruction of the pulmonary artery

Comparison

Rb86 infusion for a 10-min period vs Right vs left ventricles; controls vs pulmonary…

Design

Preclinical

Follow-up

10 minutes

Authors

WLWilliam D. LoveMitre (United States)LOL O'MeallieTulane University

Discussion

Member takes

Implication

May support Rb86-based flow estimation across ventricles in animal models; leaves open human validation without catheterization.

Key Points

The study evaluates the correlation between myocardial clearance of Rb 86 and coronary blood flow in the right and left ventricles.
Simultaneous measurement of Rb 86 clearance and coronary blood flow during a 10-min isotope infusion in dogs.
Use of the Fick principle to measure blood flow separately for the right and left ventricles.
Collection of venous blood from the anterior cardiac vein and the coronary sinus.
No significant difference in blood flow-Rb 86 clearance relationship between right and left ventricles identified.
At flow rates <6 ml/g 10 min, mean error in predicting flow from clearance was 4.7%.
At 6-12 ml/g 10 min, mean error was 10.0% in controls and 14.4% in those with pulmonary embolism or artery obstruction.

Structured PICO

Population

Dogs, including controls and a group with pulmonary embolism or obstruction of the pulmonary artery

Intervention

Rb86 infusion for a 10-min period

Comparator

Right vs left ventricles; controls vs pulmonary embolism/obstruction group

Outcome

Relationship of myocardial blood flow (measured by Fick principle) and Rb86 clearancesurrogate

Rb86 clearance can be used to estimate coronary blood flow without requiring cardiac vein catheterization, with acceptable error at lower flow rates.

Cite This Study

Love et al. (1963) studied this question.

synapsesocial.com/papers/6a76b80d9d809400dabd4472 https://doi.org/10.1152/ajplegacy.1963.205.2.382

Topics

Pulmonary embolism

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Relationship of blood flow and myocardial Rb86 clearance in right and left ventricles

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Relationship of blood flow and myocardial Rb86 clearance in right and left ventricles

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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