What question did this study set out to answer?

To compare left coronary blood flow measured by rubidium-86 clearance against mechanical rotameter metering under varying flow rates and states of myocardial oxygenation and function.

October 1, 1966Circulation ResearchOpen Access

Measurement of Coronary Blood Flow in Dogs with Normal and Abnormal Myocardial Oxygenation and Function

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Authors

TMTHOMAS W. MOIRUniversity Hospitals of Cleveland

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Implication

Experimental animal study reveals Rubidium-86 clearance underestimates metered coronary blood flow in anesthetized dogs, indicating limited utility for absolute quantitative measurement.

Key Points

To compare left coronary blood flow measured by rubidium-86 clearance against mechanical rotameter metering under varying flow rates and states of myocardial oxygenation and function.
Simultaneously measured common left coronary blood flow using an in-line recording rotameter and rubidium-86 chloride clearance in anesthetized, open-chest dogs.
Evaluated tracer extraction across a broad spectrum of flow rates during both normoxia and induced myocardial hypoxia.
Rubidium-86 clearance correctly reflected directional flow changes but systematically underestimated metered flow, ranging from 27% under ischemic flow to 54% under hyperemic flow conditions.
Capillary transit time determined by the coronary flow rate served as the primary cause of clearance underestimation, regardless of myocardial hypoxia.

Cite This Study

THOMAS W. MOIR (1966) studied this question.

synapsesocial.com/papers/6a71a83dac440176ef2a4648 https://doi.org/10.1161/01.res.19.4.695

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Implication

Experimental animal study reveals Rubidium-86 clearance underestimates metered coronary blood flow in anesthetized dogs, indicating limited utility for absolute quantitative measurement.

Measurement of Coronary Blood Flow in Dogs with Normal and Abnormal Myocardial Oxygenation and Function

Discussion

Member takes

Implication

Key Points

Cite This Study

Measurement of Coronary Blood Flow in Dogs with Normal and Abnormal Myocardial Oxygenation and Function

Discussion

Member takes

Implication

Key Points

Cite This Study

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