Key result
84Rb coincidence counting reproducibly measures MBF and detects decreased flow reserve in CAD.
Why the study?
Animal and human studies were conducted to evaluate myocardial blood flow measurement by a coincidence counting system using a single bolus of 84Rb and compare it to established methods.
Can a coincidence counting system and single bolus of 84Rb accurately measure myocardial blood flow in animals and humans?
Population
Animals and humans including normal subjects and patients with significant coronary artery disease
Comparison
Coincidence counting system measurement vs concomitant Fick determination in animals
Design
Observational study
Authors
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Supports early noninvasive MBF quantification; leaves open prospective validation before clinical adoption.
Observational
Can a coincidence counting system and single bolus of 84Rb accurately measure myocardial blood flow in animals and humans?
A coincidence counting system using 84Rb provides an accurate and reproducible method for measuring myocardial blood flow and detecting decreased flow reserve in coronary artery disease.
S. B. Koebel (1971) conducted an observational in Coronary artery disease. Coincidence counting system and single bolus of 84Rb was evaluated on Myocardial blood flow (MBF). Myocardial blood flow measured by a coincidence counting system and 84Rb averaged 269±61 ml/min in normal subjects, was reproducible, and showed decreased flow reserve in coronary artery disease.
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