Key result
Quantification of myocardial blood flow with 82Rb PET demonstrated excellent concordance with 15O-water PET over the entire flow range (ρc=0.88), validating its accuracy for clinical use even at high flow rates.
Why the study?
Does 82Rb PET accurately quantify myocardial blood flow and flow reserve compared to 15O-water PET in healthy controls and patients with mild CAD?
Population
33 participants
Comparison
Myocardial blood flow measurement with 82Rb… vs Myocardial blood flow measurement with 15O-water…
Design
Cross-sectional
Authors
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May support 82Rb PET for MBF quantification in mild CAD; leaves open outcome validation before routine adoption.
Cross-Sectional (n=33)
Single-blind
Yes
Does 82Rb PET accurately quantify myocardial blood flow and flow reserve compared to 15O-water PET in healthy controls and patients with mild CAD?
Effect estimate: Lin's concordance correlation ρc 0.88 (95% CI 0.82-0.94)
82Rb PET with a newly derived correction for nonlinear extraction accurately quantifies myocardial blood flow and flow reserve compared to the 15O-water gold standard.
Prior et al. (2012) conducted a cross-sectional in Coronary Artery Disease (n=33). 82Rb positron emission tomography vs. 15O-water positron emission tomography was evaluated on Concordance of myocardial blood flow (MBF) measurements between 82Rb and 15O-water (Lin's concordance correlation ρc 0.88, 95% CI 0.82-0.94). Quantification of myocardial blood flow with 82Rb PET demonstrated excellent concordance with 15O-water PET over the entire flow range (ρc=0.88), validating its accuracy for clinical use even at high flow rates.
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