Key result
Myocardial blood flow estimated with a two-compartment model from 82Rb kinetics correlated well with directly measured myocardial blood flow in isolated rabbit septa (r = 0.91; slope = 1.03).
Population
24 isolated, arterially perfused rabbit interventricular septa
Design
Preclinical
Authors
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Supports two-compartment 82Rb modeling in rabbit myocardium; leaves open human validation before clinical perfusion imaging.
Effect estimate: r = 0.91
A two-compartment model adequately describes 82Rb kinetics in rabbit myocardium and accurately estimates myocardial blood flow.
Huang et al. (1989) studied Myocardial blood flow estimation (n=24). 82Rb kinetic experiments and compartmental modeling vs. Directly measured myocardial blood flow was evaluated on Correlation between estimated MBF and directly measured MBF (r = 0.91). Myocardial blood flow estimated with a two-compartment model from 82Rb kinetics correlated well with directly measured myocardial blood flow in isolated rabbit septa (r = 0.91; slope = 1.03).
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