Population
Working dog heart model (anterior descending branch of the left common coronary artery perfused)
Design
Preclinical
Authors
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Distinguishes flow-dependent capillary from flow-independent cellular rubidium kinetics in dogs; extends tracer models but leaves open human translation.
In a dog model, rubidium exchange at the capillary wall is flow-dependent, whereas myocardial cell uptake is independent of flow, providing foundational kinetic data for rubidium tracers.
Ziegler et al. (1971) studied this question.
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