May 1, 1995Circulation Research

Pathways of Rb+Influx and Their Relation to Intracellular Na+ in the Perfused Rat Heart

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Population

Perfused rat hearts

Comparison

Infusion of K+ and Na+ transport system… vs Untreated perfused rat hearts

Design

Preclinical

Authors

VKValerie V. KupriyanovSevertsov Institute of Ecology and Evolution LSLaura C. StewartBrigham and Women's Hospital BXBo XiangJishou University

Discussion

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Implication

Enables experimental Na+ influx quantification in isolated hearts; leaves open translation to human models or practice.

Structured PICO

Population

Perfused rat hearts

Intervention

Infusion of K+ and Na+ transport system inhibitors (procaine, lidocaine, ouabain, 4-aminopyridine, bumetanide, dimethylamiloride) and Na+ ionophore (monensin)

Comparator

Untreated perfused rat hearts (beating or arrested)

Outcome

Rb+ influx rate and intracellular Na+ concentration ([Na+]i) measured by 87Rb and 23Na NMR spectroscopysurrogate

In perfused rat hearts, Rb+ influx occurs primarily via the Na+,K+-ATPase and can serve as a reliable measure of Na+ influx, with Na+ channels providing at least 50% of Na+ entry into beating cardiac cells.

Cite This Study

Kupriyanov et al. (1995) studied this question.

synapsesocial.com/papers/6a8a87a11fb56efa37d4a850 https://doi.org/10.1161/01.res.76.5.839

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Pathways of Rb+Influx and Their Relation to Intracellular Na+ in the Perfused Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathways of Rb+Influx and Their Relation to Intracellular Na+ in the Perfused Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider