Population
Sheep cardiac Purkinje fibres
Comparison
Varying concentrations of external rubidium ions… vs Rb-free, K-free solutions and varying holding…
Design
Preclinical
Authors
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May inform models of Na regulation in cardiac cells; leaves open translation to human electrophysiology or therapies.
In sheep cardiac Purkinje fibres, intracellular sodium activity is dependent on external rubidium concentration (reflecting Na-K pump activation) and membrane potential (modulating passive Na influx).
Eisner et al. (1981) studied this question.
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