December 2, 2009Nuclear Medicine Communications
3D versus 2D dynamic 82Rb myocardial blood flow imaging in a canine model of stunned and infarcted myocardium
Why the study?
Does 3D 82Rb PET imaging provide comparable myocardial blood flow measurements to 2D imaging in a canine model?
Population
Canine model of stunned and infarcted myocardium
Comparison
Three-dimensional rubidium-82 positron emission… vs Two-dimensional (2D) 82Rb PET imaging
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports 3D MBF feasibility in canines; leaves open human translation and dose-reduction potential.
Structured PICO
Does 3D 82Rb PET imaging provide comparable myocardial blood flow measurements to 2D imaging in a canine model?
P
Population
Canine model of stunned and infarcted myocardium
I
Intervention
Three-dimensional (3D) rubidium-82 (82Rb) positron emission tomography (PET) imaging
C
Comparator
Two-dimensional (2D) 82Rb PET imaging
O
Outcome
Myocardial blood flow (MBF) in ml/min/gsurrogate
3D 82Rb PET imaging provides comparable myocardial blood flow measurements to traditional 2D imaging in a canine model, suggesting potential for lower administered activity and reduced costs.
Cite This Study
Lekx et al. (2009) studied this question.