Key result
Myocardial metabolic rates of glucose calculated using the FDG tracer kinetic model were not significantly different from those determined by the Fick method (P > 0.05).
Population
Isolated arterially perfused rabbit interventricular septum
Comparison
18F-2-deoxy-2-fluoro-d-glucose constant infusion… vs Fick method for deriving myocardial metabolic…
Design
Preclinical
Authors
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Supports preclinical FDG kinetic model validation; leaves open translation to clinical PET myocardial glucose imaging.
p-value: p=>0.05
FDG with a tracer kinetic model accurately estimates myocardial glucose utilization, supporting its use with positron-computed tomography in vivo.
Krivokapich et al. (1982) studied this question. 18F-2-deoxy-2-fluoro-d-glucose (FDG) with a tracer kinetic model vs. Fick method was evaluated on Myocardial metabolic rates of glucose (MMRGlc) (p=>0.05). Myocardial metabolic rates of glucose calculated using the FDG tracer kinetic model were not significantly different from those determined by the Fick method (P > 0.05).
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