A fine pair: Excellent levels of regio-, endo/exo-, diastereo-, and/or enantioselectivity are attained in the Cu-catalyzed cycloaddition of nitrones with α′-hydroxy enones (see scheme). The resulting adducts can be further elaborated to the corresponding isoxazolidines bearing aldehyde, ketone, and carboxylic acid functions.
No takes yet. Share an insight, caveat, or question.
Palomo et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: