Key result
Preventive use of donepezil dramatically controlled prolonged post-electroconvulsive therapy delirium in a patient who was unresponsive to antipsychotics.
Why the study?
Post-electroconvulsive therapy delirium can be severe and prolonged, requiring pharmacological interventions when standard treatments fail.
Does donepezil improve prolonged post-electroconvulsive therapy delirium in patients unresponsive to antipsychotics?
Case Report (n=1)
Does donepezil improve prolonged post-electroconvulsive therapy delirium in patients unresponsive to antipsychotics?
Donepezil may be an effective intervention for severe, prolonged post-ECT delirium that is unresponsive to standard antipsychotic treatment.
May warrant consideration for refractory post-ECT delirium; hypothesis-generating and requires confirmation in controlled trials.
To the Editor: P ost–electroconvulsive therapy (ECT) delirium is not uncommon, and it occurs in up to 12% of patients. Post-ECT delirium is considered to be self-limited, and it usually lasts less than 1 hour. However, post-ECT delirium can be severe and prolonged, and it needs certain interventions, including pharmacological treatments and physical restraints. Here, we report a case of prolonged post-ECT delirium wherein the patient was unresponsive to antipsychotics but dramatically responsive to the preventive use of acetylcholine esterase inhibitor donepezil.
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Takamiya et al. (2019) conducted a case report in Prolonged post-electroconvulsive therapy (ECT) delirium (n=1). Donepezil was evaluated on Response to treatment. Preventive use of donepezil dramatically controlled prolonged post-electroconvulsive therapy delirium in a patient who was unresponsive to antipsychotics.
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