Transcatheter aortic valve implantation in patients with ascending aortic dilatation: safety of the procedure and mid-term follow-up
Key result
Concomitant ascending aortic dilatation in patients undergoing TAVI did not significantly affect 1-year survival compared to patients with a non-dilatated aorta (87% vs 83%, P=0.573).
Why the study?
Is TAVI safe and does it provide similar mid-term survival in patients with severe aortic stenosis and concomitant ascending aortic dilatation compared to those without dilatation?
Population
457 patients with severe aortic stenosis meeting inclusion criteria for TAVI, including 98 patients with…
Comparison
Transcatheter aortic valve implantation (TAVI) vs Patients with non-dilatated ascending aorta…
Design
Cohort
Follow-up
median 14 months
Authors
Discussion
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Implication
Supports TAVI feasibility with aortic dilatation; leaves open need for longer-term and randomized data.
Study Design
Type
Cohort (n=457)
Structured PICO
Is TAVI safe and does it provide similar mid-term survival in patients with severe aortic stenosis and concomitant ascending aortic dilatation compared to those without dilatation?
P
Population
457 patients with severe aortic stenosis undergoing TAVI, including 98 with concomitant ascending aortic dilatation, followed for a median of 14 months.
E
Exposure
Transcatheter aortic valve implantation (TAVI)
C
Comparator
Patients with non-dilatated ascending aorta undergoing TAVI
O
Outcome
Safety of the procedure (iatrogenic dissection, intraoperative aortic rupture) and 1-year survivalsafety
Main Result
Absolute Event Rate: 87% vs 83%
p-value: p=0.573
TAVI is safe and provides similar mid-term survival in patients with severe aortic stenosis and concomitant ascending aortic dilatation compared to those without dilatation.
Cite This Study
Rylski et al. (2014) conducted a cohort in Severe aortic stenosis (n=457). Ascending aortic dilatation vs. Non-dilatated ascending aorta was evaluated on 1-year survival (p=0.573). Concomitant ascending aortic dilatation in patients undergoing TAVI did not significantly affect 1-year survival compared to patients with a non-dilatated aorta (87% vs 83%, P=0.573).