Key result
Progranulin and its engineered derivative Atsttrin act as antagonists of TNFα signaling, providing potential new therapeutic interventions for rheumatoid arthritis and other inflammatory conditions.
Population
Inflammatory arthritis models and rheumatoid arthritis
Design
Review
Authors
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Does not support immediate clinical adoption in rheumatoid arthritis; leaves open further development of progranulin-based TNFα antagonists.
Progranulin and its engineered derivative Atsttrin represent promising therapeutic interventions for TNFα-mediated pathologies like rheumatoid arthritis.
Liu C (2011) conducted a review in Rheumatoid arthritis. Progranulin (PGRN) and Atsttrin was evaluated. Progranulin and its engineered derivative Atsttrin act as antagonists of TNFα signaling, providing potential new therapeutic interventions for rheumatoid arthritis and other inflammatory conditions.
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