Comparison of Dexmedetomidine With Fentanyl in Attenuation of Pressor Response to Laryngoscopy and Intubation

BACKGROUND laryngoscopy and endotracheal intubation elicits a haemodynamic response associated with increased heart rate and pressure. aim of the study is to compare the efficacy of intravenous dexmedetomidine and fentanyl in attenuation of stress to laryngoscopy and intubation. AND METHODS was carried out on 60 patients belonging to ASA grade I & II, aged 15 to 65 years including either gender scheduled for surgical procedures under general anaesthesia in Osmania General Hospital. Patients were randomly divided into two of 30 each. Group D received 0.6g/kg dexmedetomidine and Group F received 2 g/kg fentanyl diluted in 10 mL saline 10 minutes before laryngoscopy and intubation. Anaesthesia was standardised in both groups and vital heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded , during intubation and up to 10 minutes after intubation. groups were well matched for their demographic data. It was observed that increase in heart rate, systolic blood , diastolic blood pressure and mean arterial pressure after intubation was highly significant in fentanyl group as to dexmedetomidine. There was a statistically significant difference (P <0.05) between dexmedetomidine and groups in heart rate, systolic, diastolic blood pressure and mean arterial pressure at all time points after tracheal . the drugs attenuated the pressor response. Among the two drugs administered dexmedetomidine 0.6 µg/kg provides and effective attenuation of pressor response to laryngoscopy and tracheal intubation when compared to fentanyl in a of 2 µg/kg.