Key result
Intravenous labetalol (0.4 mg/kg) significantly attenuated the rise in heart rate and blood pressure following laryngoscopy and intubation compared to lignocaine and placebo.
RCT (n=90)
Double-blind
Randomized into three treatment groups
No
May support labetalol for intubation hemodynamics; leaves open larger trials before practice change.
Laryngoscopy and intubation violates the patient's protective airway reflexes and lead to physiological changes involving various systems of the body. Reflex changes in the cardiovascular system are most marked after laryngoscopy and intubation and leads to average increase in blood pressure by 40-50% and 20% increase in heart rate (Indian J. Anaest 2002) 45(2):104-106. The present study compare the safe and clinically effective intravenous bolus dose of labetalol and lignocaine for controlling the cardiovascular response to laryngoscopy and intubation.
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Tayung et al. (2016) conducted an RCT in Cardiovascular response to laryngoscopy and intubation (n=90). Labetalol vs. Lignocaine 1.5 mg/kg IV or Normal saline placebo was evaluated on Heart rate at 1 minute after intubation (beats per minute) (p=<0.001). Intravenous labetalol (0.4 mg/kg) significantly attenuated the rise in heart rate and blood pressure following laryngoscopy and intubation compared to lignocaine and placebo.
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