Effectiveness of two different doses of intravenous labetalol on attenuation of hemodynamic responses to laryngoscopy and intubation in controlled hypertensive patients undergoing major abdominal surgeries under general anaesthesia - A randomized trial

Introduction: Laryngoscopy and endotracheal intubation provoke physiological responses, violate thepatient’s protective airway reflexes and predictably lead to hemodynamic changes. The present studywas aimed to compare the effectiveness of two doses of intravenous labetalol in attenuatinghemodynamic responses associated with laryngoscopy and endotracheal intubation by observingchanges in the patient’s heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP)and mean arterial pressure (MAP). Materials and Method: This was a hospital-based randomizeddouble-blinded interventional study which included 72 patients with controlled hypertension, agedbetween 20 to 60 years, undergoing elective open abdominal surgery, requiring general anaesthesiaand orotracheal intubation. Patients were assigned into two groups of 36 each: Group A: Labetalol 0.15 mg/kg and Group B: Labetalol 0.3 mg/kg diluted with 0.9% normal saline to make up to 10 mLand was given intravenously 5 min before intubation. HR, SBP, DBP, MAP and oxygen saturation(SpO2) were recorded before induction, at the time of intubation and 1, 3, 5, and 10 min afterintubation. Results: HR, SBP, DBP and MABP were significantly attenuated in. Group B at intubation, 1 min, 3 min, 5 min, and 10 minutes after intubation. Conclusion: Labetalol in the dose of0.3 mg/kg provides better hemodynamic stability than labetalol in the dose of 0.15 mg/kg onsympathetic stimulation due to direct laryngoscopy and endotracheal intubation.