Key result
A bolus intravenous injection of 80 micrograms/kg isosorbide dinitrate significantly attenuated the hypertensive response to direct laryngoscopy and tracheal intubation (P<0.01).
Why the study?
Does intravenous isosorbide dinitrate attenuate the pressor response to laryngoscopy and tracheal intubation in patients undergoing elective surgery?
RCT (n=30)
Does intravenous isosorbide dinitrate attenuate the pressor response to laryngoscopy and tracheal intubation in patients undergoing elective surgery?
p-value: p=<0.01
A bolus intravenous injection of 80 micrograms/kg isosorbide dinitrate effectively attenuates the hypertensive response to direct laryngoscopy and tracheal intubation.
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May blunt intubation hypertension in elective cases; leaves open confirmation in larger randomized trials.
Hatano et al. (1989) conducted an RCT in Patients undergoing elective surgery (n=30). Isosorbide dinitrate (ISDN) vs. No ISDN (control) was evaluated on Mean arterial pressure (MAP) and heart rate (HR) in response to laryngoscopy and tracheal intubation (p=<0.01). A bolus intravenous injection of 80 micrograms/kg isosorbide dinitrate significantly attenuated the hypertensive response to direct laryngoscopy and tracheal intubation (P<0.01).
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