February 1, 1982Circulation

Exacerbation of vasotonic angina pectoris by propranolol.

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Why the study?

Does propranolol improve the duration and frequency of angina attacks in patients with coronary artery spasm?

Population

Patients with coronary artery spasm (vasotonic angina pectoris)

Design

Double-blind

Authors

Discussion

Propranolol monotherapy warrants avoidance in coronary spasm; challenges presumed benefit and supports testing alternatives in RCTs.

Does propranolol improve the duration and frequency of angina attacks in patients with coronary artery spasm?

Population

Patients with coronary artery spasm (vasotonic angina pectoris)

Intervention

Propranolol (low-dose 40 mg every 6 hours and high-dose 160 mg every 6 hours)

Outcome

Duration and frequency of angina attackspatient reported

Propranolol as a single therapy prolongs angina attacks in patients with coronary artery spasm and should not be used as sole treatment.

Robertson et al. (1982) studied this question.

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