What question did this study set out to answer?

To quantify the effects of propranolol on left ventricular function, wall motion, and pressure-volume relations in humans.

April 1, 1975HeartOpen Access

Effect of propranolol on left ventricular function, segmental wall motion, and diastolic pressure-volume relation in man.

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Why the study?

Does propranolol alter left ventricular function, segmental wall motion, and diastolic pressure-volume relation in humans?

Population

Human patients, including some with pre-existing myocardial disease and impaired cardiac function…

Authors

JCJ ColtartTransnational Press London EAEdwin L. AldermanBoston University SRSHERILYN C. ROBISONSt Thomas' Hospital

Discussion

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Implication

May impair LV systolic function acutely without altering compliance; leaves open effects on chronic use or clinical outcomes.

Key Points

To quantify the effects of propranolol on left ventricular function, wall motion, and pressure-volume relations in humans.
Patients received propranolol (3.15 mg/kg) and underwent left ventricular measurements.
Left ventricular pressure and volumes were analyzed via video disc and computer system.
Patients were paced to maintain a constant heart rate during measurements.
Ejection fraction may be reduced in some patients following propranolol administration due to decreased segmental wall motion.
Diastolic volume increases in patients with impaired cardiac function.
No alterations in the passive elastic properties of ventricular muscle were observed.

Structured PICO

Does propranolol alter left ventricular function, segmental wall motion, and diastolic pressure-volume relation in humans?

Population

Human patients, including some with pre-existing myocardial disease and impaired cardiac function, undergoing transvenous atrial pacing

Intervention

Propranolol (3.15 mg/kg body weight)

Outcome

Left ventricular function (ejection fraction), segmental wall motion, and diastolic pressure-volume relationsurrogate

Propranolol acutely alters left ventricular hemodynamics by reducing ejection fraction and increasing diastolic volume without changing the intrinsic passive elastic properties of the myocardium.

Cite This Study

Coltart et al. (1975) studied this question.

synapsesocial.com/papers/6a6fba3fac440176ef2861a7 https://doi.org/10.1136/hrt.37.4.357

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Effect of propranolol on left ventricular function, segmental wall motion, and diastolic pressure-volume relation in man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of propranolol on left ventricular function, segmental wall motion, and diastolic pressure-volume relation in man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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