Treatment of spontaneous angina pectoris with beta blocking agents. A clinical, electrocardiographic, and haemodynamic appraisal.
Key result
Propranolol was fully effective in 73% of type II angina cases compared to 0% for practolol, while both showed similar efficacy (38% vs 42%) in type I angina.
Why the study?
Do propranolol and practolol reduce episodes of pain and ECG abnormalities in patients with spontaneous angina pectoris?
Population
36 patients with repeated daily occurrence of spontaneous angina.
Design
Cohort
Authors
Discussion
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Implication
Propranolol may be considered over practolol for type II spontaneous angina; this cohort study leaves open confirmation in randomized trials.
Structured PICO
Do propranolol and practolol reduce episodes of pain and ECG abnormalities in patients with spontaneous angina pectoris?
P
Population
36 patients with repeated daily occurrence of spontaneous angina, including 21 with ST segment depression and 15 with ST segment elevation.
I
Intervention
Propranolol and practolol at individualized doses.
O
Outcome
Efficacy evaluated subjectively (number of reported episodes of pain) and objectively (number of episodes of electrocardiographic abnormalities documented during periods of continuous recording).
Propranolol is highly effective for spontaneous angina with ST elevation (type II), whereas practolol is ineffective for this type, though both have similar efficacy in angina with ST depression.
Cite This Study
Guazzi et al. (1975) studied Spontaneous angina pectoris (n=36). Propranolol and practolol vs. Each other was evaluated on Efficacy evaluated in subjective (number of reported episodes of pain) and objective terms (number of episodes of electrocardiographic abnormalities). Propranolol was fully effective in 73% of type II angina cases compared to 0% for practolol, while both showed similar efficacy (38% vs 42%) in type I angina.