Anticoagulant Effects of Dabigatran on Coagulation Laboratory Parameters in Pediatric Patients: Combined Data from Five Pediatric Clinical Trials

Figures

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  Fig. 1. Graphical visualization of the relationships between observed aPTT, dTT, and ECT, and dabigatran total plasma concentrations. In all plots, circles are observed data from the five pediatric studies ( Table 1 ), and the dashed lines represent a model-based 95% prediction interval in healthy adults. In the aPTT plot, squares represent 4,211 data observations from 1,881 adult patients in the RE-COVER and RE-NOVATE II studies. Measurements >200 seconds ( n = 14) from six children, as well as 16 measurements from adult patients, are not displayed. In the dTT plots, squares represent 1,933 data observations from 702 adult patients in the RE-NOVATE II study. In the ECT plot, squares represent 2,285 data observations from 1,179 adult patients in the RE-COVER study. aPTT, activated partial thromboplastin time; dTT, diluted thrombin time; ECT, ecarin clotting time; sec, seconds.

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  Fig. 2. Graphical visualization of the relationships between observed aPTT, dTT, and ECT, and dabigatran total plasma concentrations by pediatric age groups. In all plots, circles are observed data from the five pediatric studies ( Table 1 ), and the dashed lines represent a model-based 95% prediction interval in healthy adults. In the aPTT plot, squares represent 4,211 data observations from 1,881 adult patients in the RE-COVER and RE-NOVATE II studies. In the dTT plots, squares represent 1,933 data observations from 702 adult patients in the RE-NOVATE II study. In the ECT plot, squares represent 2,285 data observations from 1,179 adult patients in the RE-COVER study. aPTT, activated partial thromboplastin time; dTT, diluted thrombin time; ECT, ecarin clotting time; sec, seconds.

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  Fig. 3. Population model predictions for the final aPTT, dTT, and ECT models and dabigatran total plasma concentrations, across age groups. aPTT, activated partial thromboplastin time; dTT, diluted thrombin time; ECT, ecarin clotting time.