Key result
A 37-year-old man with acquired slow-channel syndrome and acetylcholine receptor antibodies responded to pyridostigmine, highlighting the importance of AChR-Ab titers in suspected hereditary SCS.
Case Report (n=1)
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AChR-Ab titers are important in suspected cases of hereditary SCS because patients with positive AChR-Abs may have a better response to available treatments like pyridostigmine.
We report the case of a 37-year-old man with clinical and electrophysiological features of hereditary slow-channel syndrome (SCS) and antibodies against acetylcholine receptors (AChR-Abs). He presented with weakness of shoulder and hand muscles. A supramaximal single stimulus to the motor nerves disclosed a double compound muscle action potential (CMAP). Repetitive stimulation of ulnar, suprascapular, and median nerves showed a CMAP decrement greater than 10%. The patient responded to pyridostigmine. This report confirms the importance of AChR-Ab titers in suspected cases of hereditary SCS because patients with positive AChR-Abs may have a better response to available treatments.
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Scola et al. (2000) conducted a case report in Acquired slow-channel syndrome (n=1). Pyridostigmine was evaluated on Clinical response. A 37-year-old man with acquired slow-channel syndrome and acetylcholine receptor antibodies responded to pyridostigmine, highlighting the importance of AChR-Ab titers in suspected hereditary SCS.
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