Key result
Theoretical development of class IIIA antiarrhythmic agents suggests they should ideally lengthen refractoriness upon heart acceleration to exceed the tachycardia cycle length.
Design
Review
Authors
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Theoretical target for class IIIA agents guides preclinical design; leaves open clinical translation and safety.
Proposes theoretical mechanisms for developing Class IIIA antiarrhythmic agents that increase refractoriness during tachycardia rather than bradycardia.
Luc M. Hondeghem (1992) conducted a review in Arrhythmia. Class IIIA antiarrhythmic agents was evaluated. Theoretical development of class IIIA antiarrhythmic agents suggests they should ideally lengthen refractoriness upon heart acceleration to exceed the tachycardia cycle length.
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