A sticky end: Two DNA strands that produce three contiguous mismatches (5′-TGG-3′/5′-TGG-3′ sequence) do not hybridize spontaneously, but are adhered by the mismatch-binding ligand naphthyridine carbamate dimer (NC; see picture, red rectangles: naphthyridine rings).
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Peng et al. (2006) studied this question.
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